For many couples dreaming of parenthood, the journey can be long and filled with uncertainty. One of the most frustrating diagnoses they may face is unexplained infertility. Despite multiple tests and medical evaluations, no clear cause is found. This blog aims to shed light on what unexplained infertility means, its possible causes, and how it can be managed effectively.

What Is Unexplained Infertility?

Unexplained infertility is a medical condition where a couple is unable to conceive after 12 months of regular, unprotected intercourse, yet no obvious reason is found through standard fertility tests. These tests typically evaluate ovulation, sperm health, fallopian tube function, and uterine conditions. When all results appear normal, but conception still doesn’t occur, the diagnosis is termed “unexplained infertility.”

This diagnosis affects about 10-20% of infertile couples and can be emotionally draining due to the lack of a clear path forward.

Possible Causes of Unexplained Infertility

Though not always identifiable through routine testing, several subtle or complex factors could contribute to unexplained infertility:

• Egg quality decline – Especially in women over 35. 
• Mild endometriosis – Not always detectable through basic imaging. 
• Sperm DNA fragmentation – Even when sperm count and motility are normal. 
• Immune system factors, Such as antibodies affecting sperm or embryos. 
• Implantation failure – Due to issues at the molecular level in the uterus or embryo. 
• Lifestyle factors – including stress, poor diet, smoking, and excessive alcohol consumption. 

While these factors may not appear in routine tests, they can significantly affect fertility.

Diagnosis and Evaluation

The first step in addressing unexplained infertility is a thorough assessment. This includes:

• Hormonal profiling 
• Ultrasound scans 
• Ovarian reserve testing 
• Semen analysis 
• Tubal patency tests (HSG or Sonohysterogram) 

In some cases, further evaluation such as laparoscopy or advanced sperm DNA testing may be recommended.

At Samad Hospital, the best IVF hospital in Trivandrum, fertility specialists take a personalised and comprehensive approach to uncover any hidden factors that may be contributing to infertility.

Treatment Options for Unexplained Infertility

Even when a cause isn’t identified, several effective treatment strategies can improve the chances of conception:

1. Lifestyle Changes

Improving overall health can enhance fertility. This includes:

• Maintaining a healthy weight 
• Reducing caffeine and alcohol intake 
• Quitting smoking 
• Stress management through yoga, counselling, or meditation 

2. Ovulation Induction and Timed Intercourse

Medications like Clomiphene Citrate or Letrozole are often used to stimulate ovulation, followed by timed intercourse to increase the chance of pregnancy.

3. Intrauterine Insemination (IUI)

IUI involves placing washed sperm directly into the uterus around the time. It bypasses potential barriers and increases the number of sperm reaching the egg.

4. In Vitro Fertilisation (IVF)

For many couples with unexplained infertility, IVF is the most effective treatment. It allows fertilisation to happen outside the body, and embryo quality can be evaluated before transfer.

At Samad Hospital in Trivandrum, advanced IVF technologies such as embryo freezing, laser hatching, and blastocyst culture help optimise pregnancy outcomes, even in unexplained cases.

5. Use of Advanced Technologies

Techniques like Preimplantation Genetic Testing (PGT) and sperm DNA fragmentation analysis are useful in guiding further treatments when dealing with unexplained infertility.

Emotional Support and Counselling

Unexplained infertility can take a toll on mental health. The uncertainty, repeated disappointments, and societal pressure can lead to anxiety and depression. Psychological counselling and support groups can help couples cope emotionally while going through treatment.

At Samad Hospital, compassionate care is a priority. Fertility counsellors work alongside medical experts to provide both physical and emotional support to couples on their fertility journey.

Why Choose Samad Hospital for Unexplained Infertility?

Samad Hospital, known as the best IVF hospital in Trivandrum, offers a combination of medical excellence, advanced technology, and compassionate care. Their team of fertility specialists is equipped to investigate and treat even the most complex infertility cases, including unexplained infertility.

With state-of-the-art labs, high success rates, and patient-centric care, Samad Hospital is a trusted choice for couples hoping to start their family.

Conclusion

Unexplained infertility doesn’t mean you’ve run out of options—it simply means the next steps require more precision, expertise, and sometimes, a little patience. With proper guidance and advanced reproductive techniques, many couples go on to have successful pregnancies.

If you’re facing unexplained infertility, don’t lose hope. Seek help from a qualified fertility centre like Samad Hospital in Trivandrum, and take the next step toward parenthood with confidence.